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THE TOP 5 WAYS TO OPTIMIZE WATER MONITORING

In the pharmaceutical industry, many companies are looking into Cold Water for Injection (WFI), which is produced by purification technology rather than distillation. Cold WFI offers a variety of cost advantages and high-speed production, making it more popular than ever in the industry.

For years, the European Pharmacopeia (EP) was not accepting of the WFI process, stating that any water that was not distilled would be susceptible to growth through biofilm. However, as membrane technology continued to advance, the EP began to accept other methods of purification to be equally effective as distillation. This change shifted the pharmaceutical industry away from traditional methods and into optimal Cold WFI production.

In order to ensure water is properly monitored and of the highest quality, companies should optimize their current strategies. In a recent article, Mettler Toledo goes over the five ways they enhance their water monitoring techniques, including:

Monitoring conductivity, TOC and microbes.
One way to properly monitor water is by keeping track of conductivity, microbes and total organic carbon (TOC) found in the water. These measurement points can be used to develop trend data that constantly shows the status of your water system and will alert you of any variations that may require immediate action. By taking advantage of trend data, companies will be able to easily improve their detection rates and catch issues before they begin.

Real-time microbial monitoring for ensuring water system control.

For pharmaceutical manufacturers, consistently measuring microbial for real-time analysis is critical to reaching the proper quality of water. With the Mettler Toledo on-line 7000RMS™ microbial detection analyzer, companies can do just that. This microbial monitoring system improves process efficiency, reduces downtime, allows for more production time, and increases control with minimal risks.

Conductivity measurement to meet pharmacopeia compliance.

The conductivity limits of pharmaceutical bulk water must meet the requirements of the applicable pharmacopeia. The conductivity equipment must also comply with the calibration requirements to meet all global pharmacopeias. Therefore, it is critical that all conductivity measurement devices meet the compliance of all regulatory parties involved to ensure their job is being done efficiently and effectively.

Total organic carbon continuous water monitoring.
Total organic carbon measurement must be extremely accurate for the TOC sensor. It’s also important to have equipment that can produce intelligent diagnostics and quick, simple maintenance to avoid prolonged downtime. TOC monitoring systems must be powerful and reliable, like the Mettler Toledo on-line TOC sensor, which provides rapid and precise measurements for leading biopharma companies.

Trace ozone measurement to confirm complete sanitization.

Ozone is being used increasingly in the sanitation process of pharma water systems. Dissolved ozone, a naturally occurring form of oxygen, is one of the most aggressive oxidizers used to control biological contamination. This method is extremely effective since it can quickly destroy biofilm and aqueous microbial contamination. Manufacturers should take advantage of ozone tracing technologies to ensure complete sanitation is achieved.

Learn more about water monitoring in Mettler Toledo’s whitepaper, “5 Ways to Optimize Water Monitoring.”

View the whitepaper here.

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